Secondary Effects of DHT It is well known that DHT is linked to androgenetic alopecia. It's also quite well known that the drug finasteride can help reduce the rate at which this type of hair loss develops (and may even encourage new hair growth for some people). However, it is not so well known that the purpose of DHT in the body is for hair growth, not hair loss. This steroid hormone is used by the body to promote the growth of bone, muscle and hair. I believe the primary effect of DHT in the hair loss process is that it contributes to skull expansion by stimulating certain skull bones to grow. But DHT also has a secondary effect. This newsletter explains what this secondary effect is, and how finasteride provides some resistance to it. Hair loss develops because skull expansion causes a reduction in the capillary blood supply to the hair follicles. Eventually, this causes follicle miniaturization which chokes hair growth. The body reacts to this by starting "upregulation" (hyperandrogenicity). This means that the body tries to restore normal healthy hair growth again by increasing DHT production* within the follicles that are affected by skull expansion. * Remember, that's what DHT does: it stimulates growth, not loss. Now, higher DHT levels will accelerate mitosis (cell division) and so should help struggling hair to grow. But, when the rate of mitosis is increased, the blood supply becomes insufficient to grow hair that fast (i.e., because skull expansion has reduced the capillary blood supply). As such, the (papillae) cells in the root of the hair fail to meet the growth demand placed upon them by DHT. Instead, the result of all this extra DHT is to make the body rush through the growth phase (anagen) and reach catagen (the shedding phase) and telogen (the resting phase) much sooner than it normally would. This obviously causes the amount of hair loss to increase. It also means that more hair follicles are in the resting phase. And, whilst the hair growth cycle will restart again, strong healthy hair growth is less likely due to the progressive effects of skull expansion and further accumulation of DHT. Also, since hair growth in the outer (dermal) layer of the scalp has been restricted, DHT will instead promote more rapid cell division at a deeper level of the scalp (called the stratum germinatum layer). This interference with normal cell division can result in skin cells rising up towards the surface of the skin faster than normal, causing increased shedding of the skin - dandruff. (This was explained in a previous newsletter). Finasteride treats this secondary effect of DHT by reducing levels of 5 alpha reductase (an enzyme that converts testosterone into DHT). And so, by reducing DHT levels in this way, finasteride extends the shortened anagen phase which, of course, allows more hair to grow. However, finasteride does not reverse the miniaturization of the hair follicles. I believe this is because it does not effectively treat the skull expansion process (i.e., the underlying cause of hair follicle miniaturization). It only addresses the negative effects caused by the body when it increases DHT production (upregulation). Another problem with finasteride is that further upregulation can easily occur. Many people experience this when they start using this drug. Basically, the body can compensate for the reduction in 5 alpha reductase forced upon it by finasteride. Essentially, it tries even harder to increase the quantity of 5 alpha reductase and DHT production in the affected region of the scalp. This explains why there can be an initial increase in hair loss when people start using finasteride and again when they stop using it. Although finasteride and other drugs such as dutasteride and minoxidil are used by some people to treat hair loss, there's a risk of developing side effects. The method I used and recommend is completely drug free. You can find out more at: http://www.top-hair-loss-remedy.com/stop-hair-loss.html Note: If your email provider does not support html, just copy and paste the link above into your browser address bar. Next issue: How skull expansion explains hair transplants. See you next week, Paul Taylor P.S. This newsletter runs in a continuous sequence. This means that any issue you might have missed will cycle back round again in about 15 weeks. Copyright © Paul Taylor 2011 You are subscribed to Reverse Hair Loss Now. If you wish to remove yourself from this mailing, please click on the following URL... http://top-hair-loss-remedy.com/cgi-bin/mailout/mailmgr.cgi?us=LQ.21143619.25338636.f2cf56c7001ac439b522f84691ddb300 (If the above URL is not a link, copy-and-paste the URL into your Web browser. That will confirm your removal.) To change your e-mail address, please click on the following URL... http://top-hair-loss-remedy.com/cgi-bin/mailout/mailmgr.cgi?ca=LQ.21143619.25338636.f2cf56c7001ac439b522f84691ddb300 (If the above URL is not a link, copy-and-paste the URL into your Web browser. That will confirm your change.) |
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Tuesday, 26 July 2011
Hi Readers Here's Your Hair Loss Newsletter
Heathy 365 Newsletter from Dr Weaver-How to Eat Healthy and Enjoy It
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Tuesday, 19 July 2011
Hi Readers Here's Your Hair Loss Newsletter
And How To Treat It In the last newsletter, I explained seborrhoeic dermatitis - a skin disorder that can cause severe dandruff. But there are other types of dandruff too. So in this issue I'll explain what causes them and how to treat them. Dandruff can be caused by both internal and external factors. Internal factors include:
External factors include:
Treatment for dandruff First of all, there's no cure for dandruff. But there are plenty of things you can do to control it. |
Heathy 365 Newsletter from Dr Weaver-Find Out Your Healthy Aging Score
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Tuesday, 12 July 2011
Heathy 365 Newsletter from Dr Weaver-Why Diet Resistant Fat Develops
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Tuesday, 5 July 2011
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Hi Readers Here's Your Hair Loss Newsletter
In the last newsletter, I explained how dandruff can sometimes be linked to hair loss. I also mentioned that dihydrotestosterone (DHT) will increase sebum production which might then lead on to seborrhoeic dermatitis - a skin disorder which can cause even more dandruff! So, in this newsletter I'll explain more about seborrhoeic dermatitis, as well as other causes of dandruff, and how to treat it. Seborrhoeic dermatitis is a skin disorder that can affect the scalp, face and trunk. Symptoms include scaly, flaky, itchy, red or inflamed skin as you can see from the picture below. When it affects the scalp it can also cause severe dandruff (usually forming larger, greasier flakes than other types of dandruff).
Whilst its cause remains unknown, there are several possible factors that may be involved: genetic, environmental, hormonal and the immune system. However, perhaps the most likely cause is the yeast (or fungus) called malassezia furfur* (which was formerly known as pityrosporum ovale). It's possible that an inflammatory response to this yeast might occur. Research also suggests that, since seborrhoeic dermatitis mostly affects areas where sebaceous glands are abundant (i.e., the scalp), this yeast feeds upon the sebum these glands produce, allowing it to proliferate. This theory is also supported by the fact that anti-fungal agents have proven effective against this condition. This yeast usually exists on your body and scalp all the time without causing any problems. So it may well be that a combination of high sebum levels and inadequate washing is what triggers this condition. Malassezia cannot live in acidic (low pH) conditions. Skin has a slightly acidic pH of 5. But, oils (including sebum) do not have a pH value. So, if your scalp is constantly saturated in sebum, your scalp may be open to the spread of seborrhoeic dermatitis. Shampoos can vary in pH between 4 and 8.5 but anti-dandruff shampoos should be low in pH. * Note that other strains of malassezia (globosa and restricta) have also been linked to seborrhoeic dermatitis. Anti-fungal shampoos The anti-fungal agents these shampoos contain include:
Salicylic acid will remove dead skin cells and decrease the rate at which they form. Zinc pyrithione kills malassezia furfur. Selenium sulfide and Ketoconazole will each accomplish what salicylic acid and zinc pyrithione achieve combined. Research suggests that Nizoral shampoo (which contains Ketoconazole) Is the most effective anti-fungal shampoo.
This newsletter runs in a continuous sequence. This means that any issue you might have missed will cycle back round again in about 15 weeks. |
Heathy 365 Newsletter from Dr Weaver-What Is Insulin Resistance?
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